View Current Travel Advisories

Trailways Bus Tickets
from Tupelo, MS to Knoxville, TN

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Tupelo, MS to Knoxville, TN

Buses from Tupelo, MS to Knoxville, TN travel the 298mi (479.58km) journey, taking approximately 22h, 15m. Usually, there are 2 buses operating per day. While the average ticket price for this journey is around $284.46, you can find the cheapest bus tickets for as low as $219.66.

  • Distance
    298mi (479.58km)
  • Average trip duration
  • Average bus ticket price
    $284.46
  • Trips per day
    2
  • Top Carriers
    Greyhound Lines

Bus Station Information for Knoxville, TN

Knoxville

Curbside Stop, use arrow keys or tab to explore more about this bus station

Knoxville, TN 37914

Curbside Stop
Address
100 Kirkwood St 
Knoxville, TN 37914
Phone Number
(800) 858-8555
More Detailsabout Knoxville Curbside Stop

City InformationforTupelo, MS

Looking for a town that sings with charm and history? Hop on a bus to Tupelo, MS, the birthplace of none other than Elvis Presley. Here, musical echoes fill the air, offering a unique sense of place that's both inviting and lively.

Kick off your visit with a stop at the Elvis Presley Birthplace, where you can explore his humble beginnings and see where the King of Rock 'n' Roll first caught the rhythm. But Tupelo isn't just about Elvis. Head downtown to discover a vibrant local scene filled with eclectic shops and cafes that beckon with Southern hospitality.

Outdoor enthusiasts will delight in the Tupelo Buffalo Park and Zoo, home to exotic animals and plenty of room to roam. Or maybe you'd rather enjoy a leisurely walk along the scenic Natchez Trace Parkway.

Tupelo’s blend of small-town charm and rich history is perfect for those ready to discover something special. Book that bus ticket to Tupelo, MS today, and you'll be singing its praises in no time!

City InformationforKnoxville, TN

Roll into Knoxville, TN on a fresh set of wheels and you're in for a symphony of Southern charm and unique attractions. Nestled in the breathtaking Tennessee River Valley, this vibrant town weaves the spirit of the Smoky Mountains with its own eclectic mix of history, culture, and entertainment. Travel back in time with a visit to the historic Market Square, where street performers and local artists add a splash of color to your day. Feel the buzz at the Knoxville Museum of Art or catch a live performance at the Tennessee Theatre, where the melodies linger long after the curtains close.

Nature enthusiasts will delight in the Urban Wilderness, offering miles of trails that wind through lush landscapes just minutes from the city center. And hey, if you’re a college sports fan, catch a Tennessee Volunteers game and join the sea of orange at Neyland Stadium. Hop on a bus to Knoxville and immerse yourself in a town where every corner tells a story worth uncovering. Whether you're exploring solo or with a crew, Knoxville's welcoming warmth and dynamic spirit make it a road trip worth taking.

Frequently Asked Questions about the Bus Ride

Make it easy to get from Tupelo to Knoxville by taking a bus. You can take one of our 2 daily trips from Tupelo to Knoxville for prices starting from $219.66. Get your bus ticket to Knoxville now!