View Current Travel Advisories

Trailways Bus Tickets
from Tupelo, MS to Florence, SC

(*) indicates a required field

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Tupelo, MS to Florence, SC

Buses from Tupelo, MS to Florence, SC travel the 508mi (817.54km) journey, taking approximately 23h, 50m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $163.34, you can find the cheapest bus tickets for as low as $163.34.

  • Distance
    508mi (817.54km)
  • Average trip duration
  • Average bus ticket price
    $163.34
  • Trips per day
    1
  • Top Carriers
    Greyhound Lines

Bus Station Information for Florence, SC

Florence

Bus Station, use arrow keys or tab to explore more about this bus station

Florence, SC 29501

Bus Station
Address
611 South Irby Street 
Florence, SC 29501
Phone Number
(800) 858-8555
More Detailsabout Florence Bus Station

Florence (TA Travel Center)

Curbside Stop, use arrow keys or tab to explore more about this bus station

Florence, SC 29501

24 Hours
Curbside Stop
Address
2301 W. Lucas St 
Florence, SC 29501
Phone Number
(858) 800-8898
More Detailsabout Florence (TA Travel Center) Curbside Stop

City InformationforTupelo, MS

Looking for a town that sings with charm and history? Hop on a bus to Tupelo, MS, the birthplace of none other than Elvis Presley. Here, musical echoes fill the air, offering a unique sense of place that's both inviting and lively.

Kick off your visit with a stop at the Elvis Presley Birthplace, where you can explore his humble beginnings and see where the King of Rock 'n' Roll first caught the rhythm. But Tupelo isn't just about Elvis. Head downtown to discover a vibrant local scene filled with eclectic shops and cafes that beckon with Southern hospitality.

Outdoor enthusiasts will delight in the Tupelo Buffalo Park and Zoo, home to exotic animals and plenty of room to roam. Or maybe you'd rather enjoy a leisurely walk along the scenic Natchez Trace Parkway.

Tupelo’s blend of small-town charm and rich history is perfect for those ready to discover something special. Book that bus ticket to Tupelo, MS today, and you'll be singing its praises in no time!

City InformationforFlorence, SC

All aboard for a delightful journey to Florence, SC, a charming town with Southern hospitality at its core. When your bus to Florence rolls in, get ready for a blend of culture, history, and good old-fashioned fun. Art lovers, kick off your adventure at the Florence County Museum and immerse yourself in regional history and breathtaking exhibits.

Craving outdoor activities? Hop on over to the Florence Rail Trail for a leisurely bike ride or a scenic walk amidst nature. If you fancy a bit of retail therapy, the Magnolia Mall will scratch that itch with a mix of national brands and local treasures. And speaking of local vibes, explore the downtown area with its quaint shops and lively arts scene.

Hungry after all that exploring? Florence has some delicious Southern cuisine options waiting to tantalize your taste buds. Before you hit the road, don't forget to snap a pic at the iconic Florence Veterans Park. With so much to discover, your ticket to Florence, SC, promises an adventure filled with laughs, local charm, and memories you'll cherish for years to come.

Frequently Asked Questions about the Bus Ride

Enjoy an effortless bus journey from Tupelo to Florence. Buses depart from Tupelo to Florence 1 time per day. Prices start at $163.34. Get your bus ticket to Florence today!

Other Popular Routes for Tupelo, SC and Florence, SC

Discover our Most Popular Routes Nationwide