
Buses from San Francisco, CA to Mesa, AZ travel the 667mi (1073.43km) journey, taking approximately 19h, 40m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $192.93, you can find the cheapest bus tickets for as low as $192.93.
Mesa, AZ 85210
When the fog rolls into San Francisco, CA, it's like a cozy invitation to savor a town bursting with iconic charm. Take your next adventure on a bus to San Francisco, and you'll find more delights than just the Golden Gate Bridge. Begin at Fisherman’s Wharf, where street performers add a whimsical touch, and sample world-class seafood. History enthusiasts will love wandering through the haunting walls of Alcatraz Island, while culture vultures can revel in the vast collections within the San Francisco Museum of Modern Art.
For a taste of the local vibe, hop on a cable car and ride through the quirky streets of Haight-Ashbury or explore the vibrant shops and eateries that make Chinatown sing with flavor. Green thumbs (and photographers) shouldn’t miss the Botanical Gardens in Golden Gate Park for a tranquil escape. Whether it’s the distinctive neighborhoods or the panoramic city views from Twin Peaks, every corner of San Francisco is ready to enchant you, especially when you roll into town with the reliable comfort of a Trailways bus.






Nestled amidst the sun-drenched beauty of the Sonoran Desert, Mesa, AZ, offers a vibrant tapestry of culture, adventure, and unique charm waiting to be unraveled. As you glide into town on a comfortable bus to Mesa, get ready to be greeted by its warm local vibe and endless possibilities for exploration.
Nature enthusiasts will relish in the scenic wonder of Usery Mountain Regional Park, perfect for an invigorating hike or a serene picnic. For a taste of local culture, wander through the Mesa Arts Center, home to exquisite galleries and live performances. Feeling the call of adventure? Try paddleboarding on the serene Salt River or take a leisurely stroll through the Desert Botanical Garden.
Mesa’s dining scene, a delicious fusion of southwestern flavors and farm-to-table freshness, will have you coming back for seconds. With local artisans creating delightful keepsakes, the town doesn’t just offer experiences, it leaves imprints. Hop on a bus to Mesa, AZ, and discover the magic this dynamic city has in store.
How long does it take to get from San Francisco to Mesa?
How many buses are there from San Francisco to Mesa?
How early should I arrive at San Francisco?
What is the average cost of the trip?
What bus companies offer services?
How long does it take?
What if my question isn't listed?