View Current Travel Advisories

Trailways Bus Tickets
from Orangeburg, SC to Louisville, KY

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Orangeburg, SC to Louisville, KY

Buses from Orangeburg, SC to Louisville, KY travel the 431mi (693.63km) journey, taking approximately 21h, 7m. Usually, there are 5 buses operating per day. While the average ticket price for this journey is around $139.16, you can find the cheapest bus tickets for as low as $128.83.

  • Distance
    431mi (693.63km)
  • Average trip duration
  • Average bus ticket price
    $139.16
  • Trips per day
    5
  • Top Carriers
    Greyhound Lines, FlixBus

Bus Station Information for Louisville, KY

Louisville

Bus Station, use arrow keys or tab to explore more about this bus station

Louisville, KY 40203

Bus Station
Address
1211 W Broadway 
Louisville, KY 40203
Phone Number
(800) 858-8555
More Detailsabout Louisville Bus Station

City InformationforOrangeburg, SC

All aboard for Orangeburg, SC, where Southern hospitality meets charming streets and captivating culture. A bus to Orangeburg is your ticket to a town that buzzes with local flavor and down-to-earth delights. Start at the beautiful Edisto Memorial Gardens, where rose blooms and river walks offer rest and relaxation. Then, take a historical detour at the I.P. Stanback Museum and Planetarium for a cosmic twist on local history.

Hungry for a taste of genuine Southern cuisine? Orangeburg’s eateries whip up comfort food that warms the soul, don’t miss the chance to savor a classic dish or two. And if music’s your jam, catch a show at the Stevenson Auditorium, where lively performances line the calendar.

With its sun-drenched days and welcoming vibe, Orangeburg beckons travelers to explore its unique mix of attractions and experiences. So pack your bags, grab your seat, and let the journey begin. Your adventure starts with a bus to Orangeburg, SC, where stories and smiles await every visitor!

City InformationforLouisville, KY

Wear your adventure hat and catch a bus to Louisville, KY, where Southern charm meets urban flair. Known for its spirited vibe, this town is famed for more than just its bourbon. Dive headfirst into the bustling cultural scene by visiting the Louisville Slugger Museum & Factory - who wouldn’t want to swing by and see the giant bat out front? Art lovers can lose themselves at the Speed Art Museum, while history enthusiasts will find the iconic Churchill Downs and Kentucky Derby Museum irresistible.

When you're ready to unwind, wander down to NuLu, the East Market District, for a taste of the town’s indie boutiques, craft eateries, and unique distilleries. And if you’re there in spring, a stroll through the lush grounds of the Waterfront Park is a must.

Louisville’s vibrant blend of tradition and modernity offers a big bang for your buck, with plenty of things to see and do without emptying your pockets. Catch that bus to Louisville and let the fun roll!

Frequently Asked Questions about the Bus Ride

Are you taking the bus from Orangeburg to Louisville? You can take one of our 5 daily trips from Orangeburg to Louisville for prices starting from $128.83. Buy your Orangeburg to Louisville bus ticket today.