View Current Travel Advisories

Trailways Bus Tickets
from Opelousas, LA to Clarksdale, MS

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Clarksdale, MS

Clarksdale (Greyhound Station)

Bus Station, use arrow keys or tab to explore more about this bus station

Clarksdale, MS 38614

Bus Station
Address
1604 N State St 
Clarksdale, MS 38614
Phone Number
(800) 231-2222
More Detailsabout Clarksdale (Greyhound Station) Bus Station

City InformationforOpelousas, LA

Get ready to fall in love with Opelousas, LA, a town that combines Southern charm and rich history with a vibrant music scene. Take a bus to Opelousas and prepare to indulge in a melange of soulful tunes and warm hospitality.

Start your adventure by strolling through Le Vieux Village, where restored historic buildings tell tales of times gone by. But don’t stop there—let the joyful notes of Zydeco lead you to the Evangeline Downs Racetrack and Casino, for sheer entertainment in Opelousas style.

Hungry for more? Feast on local specialties at any family-run eatery and you'll taste the genuine flavors of Opelousas—gumbo, boudin, and all the deliciousness that defines Cajun cooking. Don’t forget to swing by the area’s cozy art galleries and shops to pick up that perfect memento of your trip.

Whether you’re a music aficionado or a history buff on a quest for authentic culture, Opelousas offers a unique getaway. So, grab your ticket and hop on that bus to Opelousas, LA–your next unforgettable journey awaits!

City InformationforClarksdale, MS

Get ready for a journey to Clarksdale, MS, a town overflowing with soulful blues and cultural heartbeats. Known as the “Home of the Blues,” Clarksdale welcomes you with music echoing from street corners to iconic juke joints like Ground Zero Blues Club and Red’s Lounge, where the rhythm gets into your bones. But the city's pulse doesn’t stop here—it flows through the Delta Blues Museum, narrating stories of legends like Muddy Waters.

When you're not tapping your feet to a soulful tune, immerse yourself in local art at Quapaw Canoe Company or explore quirky finds at eclectic shops downtown. Stroll down the historic blues trail, which doubles as a journey through time and music. Wrap up your visit with authentic Southern cuisine that’ll make you think you’ve found the ultimate comfort food haven.

Let the town’s Blues tradition be your soundtrack. Book your bus to Clarksdale now and dive into a vibrant world where music and hospitality create an unforgettable experience!