View Current Travel Advisories

Trailways Bus Tickets
from Opelika, AL to Clarksdale, MS

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Clarksdale, MS

Clarksdale (Greyhound Station)

Bus Station, use arrow keys or tab to explore more about this bus station

Clarksdale, MS 38614

Bus Station
Address
1604 N State St 
Clarksdale, MS 38614
Phone Number
(800) 231-2222
More Detailsabout Clarksdale (Greyhound Station) Bus Station

City InformationforOpelika, AL

Welcome to Opelika, AL, where Southern charm meets vibrant energy in a delightful blend. This friendly town is brimming with unique attractions that offer the perfect escape for everyone. Wander through the historic downtown district and immerse yourself in Opelika's rich past, peppered with beautifully preserved architecture and local tales that whisper from every brick.

Feel the creative spirit at the Opelika Art Haus, where emerging talents showcase their work in an inspiring setting. If you're a nature lover, hit the trails of Chewacla State Park for a refreshing trek or a laid-back picnic by the serene waters. For a taste of local craftsmanship, visit the bustling John Emerald Distillery, known for its smooth, small-batch spirits that capture the essence of the region.

As you explore, let the flavors of the town's burgeoning food scene be your guide, delivering you to cozy cafes and family-run eateries. With so much to discover, don't wait another second—book your bus to Opelika, and let the charm unfold!

City InformationforClarksdale, MS

Get ready for a journey to Clarksdale, MS, a town overflowing with soulful blues and cultural heartbeats. Known as the “Home of the Blues,” Clarksdale welcomes you with music echoing from street corners to iconic juke joints like Ground Zero Blues Club and Red’s Lounge, where the rhythm gets into your bones. But the city's pulse doesn’t stop here—it flows through the Delta Blues Museum, narrating stories of legends like Muddy Waters.

When you're not tapping your feet to a soulful tune, immerse yourself in local art at Quapaw Canoe Company or explore quirky finds at eclectic shops downtown. Stroll down the historic blues trail, which doubles as a journey through time and music. Wrap up your visit with authentic Southern cuisine that’ll make you think you’ve found the ultimate comfort food haven.

Let the town’s Blues tradition be your soundtrack. Book your bus to Clarksdale now and dive into a vibrant world where music and hospitality create an unforgettable experience!