View Current Travel Advisories

Trailways Bus Tickets
from Natchez, MS to Columbia, MO

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Columbia, MO

Columbia (Midway Travel Plaza)

Curbside Stop, use arrow keys or tab to explore more about this bus station

Columbia, MO 65202

24 Hours
Curbside Stop
Address
6401 US Hwy 40 W 
Columbia, MO 65202
Phone Number
(800) 858-8555
More Detailsabout Columbia (Midway Travel Plaza) Curbside Stop

Columbia (Wabash Bus Station)

Bus Station, use arrow keys or tab to explore more about this bus station

Columbia, MO 65201

Bus Station
Address
126 N 10th St. 
Columbia, MO 65201
Phone Number
(573) 874-2489/(800) 858-8555
More Detailsabout Columbia (Wabash Bus Station) Bus Station

City InformationforNatchez, MS

Ready for a charming getaway that blends Southern hospitality with historical intrigue? Hop on a bus to Natchez, MS, and let this picturesque Mississippi River town work its magic. Famous for its antebellum architecture, Natchez promises a step back in time with its beautifully preserved estates like the Longwood and Rosalie mansions. You won't want to miss the Natchez Trace Parkway either—perfect for scenic hikes and a peek into Native American history.

Feel like a local by exploring the vibrant Blend of Southern culture at the Natchez Bluff, where the views are as intoxicating as the rich flavors from nearby dining spots offering delightful Southern cuisine. And if you’re visiting in the spring? The Natchez Pilgrimage will sweep you off your feet with stunning gardens and theatrical performances.

Whether it’s an afternoon at the visitor-friendly Natchez National Historical Park or a relaxing evening by the river, this town offers a treasure of experiences at every turn. So grab your tickets and let Natchez surprise you with its stories and Southern charm.

City InformationforColumbia, MO

Get ready to fall for Columbia, MO, where the charm of a college town meets lively arts and culture. Hop on a bus to Columbia and discover this vibrant hotspot known for its creative spirit and welcoming vibe. Start your adventure at the University of Missouri campus, where you can stroll through the historic quad that dates back to 1839. Art lovers will find delight at The State Historical Society of Missouri, showcasing masterpieces that chronicle local history and beyond.

For a day outdoors, the Rock Bridge Memorial State Park is your go-to for hiking and exploring its scenic trails and hidden caves. Feeling artsy? Check out the Ragtag Cinema for some indie film magic, perfect for those who enjoy films off the beaten path. And don’t leave without trying Columbia’s uniquely delicious pizza at a local favorite, Shakespeare’s, adding a flavorful touch to your trip.

With its eclectic mix of culture, nature, and a culinary scene that'll make any trip memorable, your bus ride to Columbia, MO, promises an adventure that combines the best of Midwestern hospitality and youthful energy. Ready for the ride?