View Current Travel Advisories

Trailways Bus Tickets
from Mesa, AZ to Santa Ana, CA

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Mesa, AZ to Santa Ana, CA

Buses from Mesa, AZ to Santa Ana, CA travel the 347mi (558.44km) journey, taking approximately 12h, 5m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $204.20, you can find the cheapest bus tickets for as low as $204.20.

  • Distance
    347mi (558.44km)
  • Average trip duration
  • Average bus ticket price
    $204.20
  • Trips per day
    1
  • Top Carriers
    Greyhound Lines

Bus Station Information for Santa Ana, CA

Santa Ana

Bus Station, use arrow keys or tab to explore more about this bus station

Santa Ana, CA 92701

Bus Station
Address
1000 E. Santa Ana Blvd. 
Santa Ana, CA 92701
Phone Number
(800) 858-8555
More Detailsabout Santa Ana Bus Station

City InformationforMesa, AZ

Nestled amidst the sun-drenched beauty of the Sonoran Desert, Mesa, AZ, offers a vibrant tapestry of culture, adventure, and unique charm waiting to be unraveled. As you glide into town on a comfortable bus to Mesa, get ready to be greeted by its warm local vibe and endless possibilities for exploration.

Nature enthusiasts will relish in the scenic wonder of Usery Mountain Regional Park, perfect for an invigorating hike or a serene picnic. For a taste of local culture, wander through the Mesa Arts Center, home to exquisite galleries and live performances. Feeling the call of adventure? Try paddleboarding on the serene Salt River or take a leisurely stroll through the Desert Botanical Garden.

Mesa’s dining scene, a delicious fusion of southwestern flavors and farm-to-table freshness, will have you coming back for seconds. With local artisans creating delightful keepsakes, the town doesn’t just offer experiences, it leaves imprints. Hop on a bus to Mesa, AZ, and discover the magic this dynamic city has in store.

City InformationforSanta Ana, CA

Pack your bags and jump on a bus to Santa Ana, CA, where a unique blend of culture and creativity awaits. This vibrant town, nestled in Southern California, is your gateway to excitement, with a local vibe you won't find anywhere else. Swing by the Bowers Museum to soak in fascinating global exhibits or explore the heart of the town at the Santa Ana Zoo, where exotic animals entertain visitors of all ages.

For your theatrical skip, the Yost Theater offers unforgettable live performances in a historic setting. Feeling hungry? Saunter through the 4th Street Market, where artisanal stalls serve up delicious bites that reflect the town's diverse culinary offerings. The scene doesn’t end there – street art and galleries add a splash of color throughout the city.

Santa Ana's energetic streets and cultural gems make it the perfect getaway. Whether you’re a history buff, an art lover, or just craving something tasty, getting on that "bus to Santa Ana" ensures you’re front and center for experiences that won’t disappoint.

Frequently Asked Questions about the Bus Ride

Need information on buses from Mesa to Santa Ana? Book a trip to Santa Ana from Mesa for as low as $204.20. We have 1 trip departing daily. Find your bus ticket to Santa Ana now.