View Current Travel Advisories

Trailways Bus Tickets
from Key West, FL to Lake City, FL

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Key West, FL to Lake City, FL

Buses from Key West, FL to Lake City, FL travel the 393mi (632.47km) journey, taking approximately 16h. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $160.54, you can find the cheapest bus tickets for as low as $160.54.

  • Distance
    393mi (632.47km)
  • Average trip duration
  • Average bus ticket price
    $160.54
  • Trips per day
    1
  • Top Carriers
    Greyhound Lines

Bus Station Information for Lake City, FL

Lake City

Bus Station, use arrow keys or tab to explore more about this bus station

Lake City, FL 32025

Bus Station
Address
251 S. Marion Ave. 
Lake City, FL 32025
Phone Number
(800) 858-8555
More Detailsabout Lake City Bus Station

City InformationforKey West, FL

Step aboard a bus to Key West, FL, where the laid-back island life meets vibrant culture and history! As you cruise along the Overseas Highway, prepare to be enchanted by this colorful town. Key West isn’t just sunshine and sandy beaches, though we’ve got plenty of that. It’s also home to literary legend Ernest Hemingway’s house, where roaming six-toed cats keep things interesting.

Feeling adventurous? A snorkeling tour through the coral reefs at Dry Tortugas National Park is a must. For a touch of history, Fort Zachary Taylor’s Civil War heritage and lush surroundings offer a unique blend of learning and leisure. When hunger strikes, dig into some conch fritters or savor more refined tastes at Duval Street’s eclectic mix of eateries.

With its lively art scene, whimsical architecture, and island sunsets that are pure magic, this town invites you to kick back and relax. Hop on a bus to Key West, FL, and let the adventures begin. Your island escapade awaits!

City InformationforLake City, FL

Grab your backpack and hop on a bus to Lake City, FL, a hidden gem that promises a blend of relaxation and adventure. This charming town, dotted with scenic lakes and rich history, is a perfect escape from the daily grind. Start your day exploring the Ichetucknee Springs State Park where crystal-clear springs invite you to dive right in or float leisurely on a tube.

For those intrigued by history, the Lake City Columbia County Historical Museum showcases fascinating artifacts in a picturesque 1870s-era house. And if you’re more of a thrill seeker, don’t miss the Osceola National Forest with its endless trails primed for hiking or biking amidst lush pine canopies.

If food is your love language, a stroll downtown will lead you to cozy, family-run diners serving up Southern comfort food that’ll fill both your heart and soul. Lake City’s friendly vibe invites you to unwind and explore, all while keeping your wallet happy. Book your bus to Lake City, FL today, and get ready for a charming slice of Floridian life!

Frequently Asked Questions about the Bus Ride

Make it easy to get from Key West to Lake City by taking a bus. Buses depart from Key West to Lake City 1 time per day. Prices start at $160.54. Find your bus ticket to Lake City now.