View Current Travel Advisories
Skip to Main Content
Trailways Home Page

Trailways Bus Tickets
from Key Largo, FL to San Francisco, CA

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Key Largo, FL to San Francisco, CA

Buses from Key Largo, FL to San Francisco, CA travel the 0mi (0.00km) journey, taking approximately 3d, 16h, 10m. Usually, there are 2 buses operating per day. While the average ticket price for this journey is around $534.08, you can find the cheapest bus tickets for as low as $533.72.

  • Average bus duration
  • Average bus ticket price
    $534.08
  • Trips per day
    2
  • Top Carriers
    Greyhound Lines

Bus Station Information for San Francisco, CA

San Francisco

Bus Station, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94105

Bus Station
Address
425 Mission St. 
San Francisco, CA 94105
Phone Number
(800) 858-8555
More Detailsabout San Francisco Bus Station

San Francisco (5th & Townsend)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94107

Curbside Stop
Address
409 Townsend Street 
San Francisco, CA 94107
Phone Number
(800) 858-8555
More Detailsabout San Francisco (5th & Townsend) Curbside Stop

San Francisco (Fisherman's Wharf)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94109

Curbside Stop
Address
700 Beach Street 
San Francisco, CA 94109
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Fisherman's Wharf) Curbside Stop

San Francisco (Daly City BART)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94014

Curbside Stop
Address
500 John Daly Blvd 
San Francisco, CA 94014
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Daly City BART) Curbside Stop

City InformationforKey Largo, FL

Looking for a relaxing yet adventurous escape? Key Largo, FL, has your name all over it. Known as the "Dive Capital of the World," this sun-drenched gem offers everything from underwater wonders to stunning sunsets that command your attention. Start your exploration at John Pennekamp Coral Reef State Park where unforgettable snorkeling or diving opportunities await. Nature enthusiasts will find plenty to adore at Dagny Johnson Key Largo Hammock Botanical State Park, where unique flora and fauna make every hike an adventure.

For a taste of local charm, the town's laid-back bars and oceanfront seafood shacks create a vibe that's as irresistible as its key lime pie. Whether you’re into kayaking through mangroves or just chilling beachside, there's no shortage of things to see and do around here.

Why wait? Let the salty air and turquoise waters lure you in. Book your bus to Key Largo, FL, and dive into an island lifestyle without breaking a sweat or the bank. Adventure is just a bus ride away!

City InformationforSan Francisco, CA

When the fog rolls into San Francisco, CA, it's like a cozy invitation to savor a town bursting with iconic charm. Take your next adventure on a bus to San Francisco, and you'll find more delights than just the Golden Gate Bridge. Begin at Fisherman’s Wharf, where street performers add a whimsical touch, and sample world-class seafood. History enthusiasts will love wandering through the haunting walls of Alcatraz Island, while culture vultures can revel in the vast collections within the San Francisco Museum of Modern Art.

For a taste of the local vibe, hop on a cable car and ride through the quirky streets of Haight-Ashbury or explore the vibrant shops and eateries that make Chinatown sing with flavor. Green thumbs (and photographers) shouldn’t miss the Botanical Gardens in Golden Gate Park for a tranquil escape. Whether it’s the distinctive neighborhoods or the panoramic city views from Twin Peaks, every corner of San Francisco is ready to enchant you, especially when you roll into town with the reliable comfort of a Trailways bus.

Scenic photo of San Francisco, CAScenic photo of San Francisco, CAScenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA

Frequently Asked Questions about the Bus Ride

Make your trip from Key Largo to San Francisco simple by taking the bus. Bus(es) depart from Key Largo to San Francisco 2 time(s) per day. Prices start at $533.72. Buy your bus ticket to San Francisco on our website.