View Current Travel Advisories

Trailways Bus Tickets
from Key Largo, FL to Lake City, FL

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Key Largo, FL to Lake City, FL

Buses from Key Largo, FL to Lake City, FL travel the 377mi (606.72km) journey, taking approximately 13h. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $142.93, you can find the cheapest bus tickets for as low as $142.93.

  • Distance
    377mi (606.72km)
  • Average trip duration
  • Average bus ticket price
    $142.93
  • Trips per day
    1
  • Top Carriers
    Greyhound Lines

Bus Station Information for Lake City, FL

Lake City

Bus Station, use arrow keys or tab to explore more about this bus station

Lake City, FL 32025

Bus Station
Address
251 S. Marion Ave. 
Lake City, FL 32025
Phone Number
(800) 858-8555
More Detailsabout Lake City Bus Station

City InformationforKey Largo, FL

Looking for a relaxing yet adventurous escape? Key Largo, FL, has your name all over it. Known as the "Dive Capital of the World," this sun-drenched gem offers everything from underwater wonders to stunning sunsets that command your attention. Start your exploration at John Pennekamp Coral Reef State Park where unforgettable snorkeling or diving opportunities await. Nature enthusiasts will find plenty to adore at Dagny Johnson Key Largo Hammock Botanical State Park, where unique flora and fauna make every hike an adventure.

For a taste of local charm, the town's laid-back bars and oceanfront seafood shacks create a vibe that's as irresistible as its key lime pie. Whether you’re into kayaking through mangroves or just chilling beachside, there's no shortage of things to see and do around here.

Why wait? Let the salty air and turquoise waters lure you in. Book your bus to Key Largo, FL, and dive into an island lifestyle without breaking a sweat or the bank. Adventure is just a bus ride away!

City InformationforLake City, FL

Grab your backpack and hop on a bus to Lake City, FL, a hidden gem that promises a blend of relaxation and adventure. This charming town, dotted with scenic lakes and rich history, is a perfect escape from the daily grind. Start your day exploring the Ichetucknee Springs State Park where crystal-clear springs invite you to dive right in or float leisurely on a tube.

For those intrigued by history, the Lake City Columbia County Historical Museum showcases fascinating artifacts in a picturesque 1870s-era house. And if you’re more of a thrill seeker, don’t miss the Osceola National Forest with its endless trails primed for hiking or biking amidst lush pine canopies.

If food is your love language, a stroll downtown will lead you to cozy, family-run diners serving up Southern comfort food that’ll fill both your heart and soul. Lake City’s friendly vibe invites you to unwind and explore, all while keeping your wallet happy. Book your bus to Lake City, FL today, and get ready for a charming slice of Floridian life!

Frequently Asked Questions about the Bus Ride

Make it easy to get from Key Largo to Lake City by taking a bus. Book a trip to Lake City from Key Largo for as low as $142.93. We have 1 trip departing daily. Get to Lake City affordably. Buy your bus ticket online.