View Current Travel Advisories

Trailways Bus Tickets
from Greenville, SC to Frederick, MD

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Greenville, SC to Frederick, MD

Buses from Greenville, SC to Frederick, MD travel the 416mi (669.49km) journey, taking approximately 16h, 15m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $273.21, you can find the cheapest bus tickets for as low as $273.21.

  • Distance
    416mi (669.49km)
  • Average trip duration
  • Average bus ticket price
    $273.21
  • Trips per day
    1
  • Top Carriers
    FlixBus

Bus Station Information for Frederick, MD

Frederick

Curbside Stop, use arrow keys or tab to explore more about this bus station

Frederick, MD 21701

Curbside Stop
Address
100 S. East St. 
Frederick, MD 21701
Phone Number
(800) 858-8555
More Detailsabout Frederick Curbside Stop

City InformationforGreenville, SC

Pack your bags and get ready to fall for Greenville, SC - a town bursting with Southern charm and surprises. Hop on a bus to Greenville, SC, and discover all this gem has to offer. Start your journey by wandering through Falls Park on the Reedy, where gentle waterfalls and lush gardens provide the perfect setting for a picnic or a peaceful stroll. If you’re an art enthusiast, the Greenville County Museum of Art awaits with a stunning collection, while the local galleries dotting the area are sure to catch your eye.

Looking for adventure with a side of nature? The Swamp Rabbit Trail offers a scenic route for biking or walking, weaving through the town's vibrant neighborhoods. Make sure to swing by the Greenville Zoo for a family-friendly outing with creatures from around the globe.

Greenville’s food scene is buzzing. From quaint cafes to upscale eateries, your taste buds are in for a treat. With its blend of culture, cuisine, and charming green spaces, Greenville, SC, is calling your name. Book that bus ticket, and let the adventure begin!

City InformationforFrederick, MD

Looking for a delightful escape that balances history, nature, and culinary delights? Your bus to Frederick, MD is ready to whisk you away to this charming town. Nestled in the heart of Maryland, Frederick offers a scenic blend of cobblestone streets and rolling landscapes. History buffs will absolutely adore the National Museum of Civil War Medicine, a unique stop that sheds light on fascinating 19th-century medical practices. Meanwhile, art lovers can rejoice at the vibrant offerings of the Delaplaine Arts Center.

Catch a breath of fresh air with a visit to the Great Frederick Fairgrounds or crisscross your way through picturesque Carroll Creek Park. Whispered among locals are tales of ghost tours, adding an element of intrigue to your visit. As the sun dips, meander through the streets sparkling with local eateries. Frederick’s spirited dining scene boasts everything from crabcakes to farm-fresh twists, promising palates a feast of flavor.

Seize the opportunity to create lasting memories. Book your bus tickets to Frederick, MD and let the adventure unfold!

Frequently Asked Questions about the Bus Ride

Need information on buses from Greenville to Frederick? We have multiple options (1 per day) heading from Greenville to Frederick for as little as $273.21. Get to Frederick affordably. Buy your bus ticket online.