View Current Travel Advisories

Trailways Bus Tickets
from Florence, SC to Columbia, MO

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Columbia, MO

Columbia (Midway Travel Plaza)

Curbside Stop, use arrow keys or tab to explore more about this bus station

Columbia, MO 65202

24 Hours
Curbside Stop
Address
6401 US Hwy 40 W 
Columbia, MO 65202
Phone Number
(800) 858-8555
More Detailsabout Columbia (Midway Travel Plaza) Curbside Stop

Columbia (Wabash Bus Station)

Bus Station, use arrow keys or tab to explore more about this bus station

Columbia, MO 65201

Bus Station
Address
126 N 10th St. 
Columbia, MO 65201
Phone Number
(573) 874-2489/(800) 858-8555
More Detailsabout Columbia (Wabash Bus Station) Bus Station

City InformationforFlorence, SC

All aboard for a delightful journey to Florence, SC, a charming town with Southern hospitality at its core. When your bus to Florence rolls in, get ready for a blend of culture, history, and good old-fashioned fun. Art lovers, kick off your adventure at the Florence County Museum and immerse yourself in regional history and breathtaking exhibits.

Craving outdoor activities? Hop on over to the Florence Rail Trail for a leisurely bike ride or a scenic walk amidst nature. If you fancy a bit of retail therapy, the Magnolia Mall will scratch that itch with a mix of national brands and local treasures. And speaking of local vibes, explore the downtown area with its quaint shops and lively arts scene.

Hungry after all that exploring? Florence has some delicious Southern cuisine options waiting to tantalize your taste buds. Before you hit the road, don't forget to snap a pic at the iconic Florence Veterans Park. With so much to discover, your ticket to Florence, SC, promises an adventure filled with laughs, local charm, and memories you'll cherish for years to come.

City InformationforColumbia, MO

Get ready to fall for Columbia, MO, where the charm of a college town meets lively arts and culture. Hop on a bus to Columbia and discover this vibrant hotspot known for its creative spirit and welcoming vibe. Start your adventure at the University of Missouri campus, where you can stroll through the historic quad that dates back to 1839. Art lovers will find delight at The State Historical Society of Missouri, showcasing masterpieces that chronicle local history and beyond.

For a day outdoors, the Rock Bridge Memorial State Park is your go-to for hiking and exploring its scenic trails and hidden caves. Feeling artsy? Check out the Ragtag Cinema for some indie film magic, perfect for those who enjoy films off the beaten path. And don’t leave without trying Columbia’s uniquely delicious pizza at a local favorite, Shakespeare’s, adding a flavorful touch to your trip.

With its eclectic mix of culture, nature, and a culinary scene that'll make any trip memorable, your bus ride to Columbia, MO, promises an adventure that combines the best of Midwestern hospitality and youthful energy. Ready for the ride?