View Current Travel Advisories

Trailways Bus Tickets
from Columbus, OH to Cape Girardeau, MO

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Columbus, OH to Cape Girardeau, MO

Buses from Columbus, OH to Cape Girardeau, MO travel the 399mi (642.13km) journey, taking approximately 13h, 45m. Usually, there are 4 buses operating per day. While the average ticket price for this journey is around $157.72, you can find the cheapest bus tickets for as low as $157.70.

  • Distance
    399mi (642.13km)
  • Average trip duration
  • Average bus ticket price
    $157.72
  • Trips per day
    4
  • Top Carriers
    FlixBus, Greyhound Lines

Bus Station Information for Cape Girardeau, MO

Cape Girardeau

Curbside Stop, use arrow keys or tab to explore more about this bus station

Cape Girardeau, MO 63701

Curbside Stop
Address
49 Leming Ln 
Cape Girardeau, MO 63701
Phone Number
(800) 858-8555
More Detailsabout Cape Girardeau Curbside Stop

City InformationforColumbus, OH

Pack your bags because Columbus, OH, is where your next adventure awaits! With a bus to Columbus, you'll find yourself in a city that seamlessly blends innovative spirit with Midwest charm. Start your journey at the fascinating Franklin Park Conservatory, where lush gardens and vibrant exhibitions create an unforgettable experience. More interested in hands-on science exploration? Dive into the interactive world of COSI (Center of Science and Industry) instead.

For art enthusiasts, the city's Short North Arts District is a must, teeming with galleries and boutiques that showcase the creativity local artists infuse into every corner. History buffs won’t want to skip the Ohio Statehouse or German Village, where the cobblestone streets whisper tales from the past.

And of course, no trip to Columbus would be complete without sampling some local culinary delights. Grab a bite at one of the beloved eateries lining the vibrant North Market, and wash it down with a local brew.

Hop on that bus to Columbus—you’re set for a getaway filled with discoveries in the heart of Ohio.

Scenic photo of Columbus, OHScenic photo of Columbus, OHScenic photo of Columbus, OH
Scenic photo of Columbus, OH
Scenic photo of Columbus, OH
Scenic photo of Columbus, OH

Frequently Asked Questions about the Bus Ride

Are you taking the bus from Columbus to Cape Girardeau? We have daily departures from Columbus to Cape Girardeau starting as low as $157.70. Get your bus ticket to Cape Girardeau now!