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Trailways Bus Tickets
from Big Pine Key, FL to San Francisco, CA

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Overview

About buses from Big Pine Key, FL to San Francisco, CA

Buses from Big Pine Key, FL to San Francisco, CA travel the 2565mi (4127.96km) journey, taking approximately 3d, 16h, 25m. Usually, there are 2 buses operating per day. While the average ticket price for this journey is around $606.27, you can find the cheapest bus tickets for as low as $606.27.

  • Distance
    2565mi (4127.96km)
  • Average trip duration
  • Average bus ticket price
    $606.27
  • Trips per day
    2
  • Top Carriers
    Greyhound Lines

Bus Station Information for San Francisco, CA

San Francisco

Bus Station, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94105

Bus Station
Address
425 Mission St. 
San Francisco, CA 94105
Phone Number
(800) 858-8555
More Detailsabout San Francisco Bus Station

San Francisco (5th & Townsend)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94107

Curbside Stop
Address
409 Townsend Street 
San Francisco, CA 94107
Phone Number
(800) 858-8555
More Detailsabout San Francisco (5th & Townsend) Curbside Stop

San Francisco (Fisherman's Wharf)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94109

Curbside Stop
Address
700 Beach Street 
San Francisco, CA 94109
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Fisherman's Wharf) Curbside Stop

San Francisco (Daly City BART)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94014

Curbside Stop
Address
500 John Daly Blvd 
San Francisco, CA 94014
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Daly City BART) Curbside Stop

City InformationforBig Pine Key, FL

Take a bus to Big Pine Key, FL, and immerse yourself in the idyllic heart of the Florida Keys. This laid-back town is a slice of paradise where natural beauty and relaxation collide. Known for its stunning landscapes and famous Key deer, the town offers a unique charm that’ll leave you longing for more.

Kick off your adventure with a visit to the National Key Deer Refuge, where you can watch these gentle creatures roam freely. For water enthusiasts, the crystal-clear waters beckon for kayaking or snorkeling trips in the nearby Looe Key Reef. Sun-seekers will love the sandy stretches of Bahia Honda State Park, perfect for unwinding under the swaying palms.

Beyond nature, Big Pine Key serves up a delightful local flair with its quirky shops and eateries. Catch a sunset and maybe even a live music performance at one of the waterfront spots that locals love.

Why wait any longer? Your blissful island escape awaits, so grab your bus tickets to Big Pine Key and let the adventure begin!

City InformationforSan Francisco, CA

When the fog rolls into San Francisco, CA, it's like a cozy invitation to savor a town bursting with iconic charm. Take your next adventure on a bus to San Francisco, and you'll find more delights than just the Golden Gate Bridge. Begin at Fisherman’s Wharf, where street performers add a whimsical touch, and sample world-class seafood. History enthusiasts will love wandering through the haunting walls of Alcatraz Island, while culture vultures can revel in the vast collections within the San Francisco Museum of Modern Art.

For a taste of the local vibe, hop on a cable car and ride through the quirky streets of Haight-Ashbury or explore the vibrant shops and eateries that make Chinatown sing with flavor. Green thumbs (and photographers) shouldn’t miss the Botanical Gardens in Golden Gate Park for a tranquil escape. Whether it’s the distinctive neighborhoods or the panoramic city views from Twin Peaks, every corner of San Francisco is ready to enchant you, especially when you roll into town with the reliable comfort of a Trailways bus.

Scenic photo of San Francisco, CAScenic photo of San Francisco, CAScenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA

Frequently Asked Questions about the Bus Ride

Make your trip from Big Pine Key to San Francisco simple by taking the bus. There are 2 trips leaving Big Pine Key and arriving in San Francisco about 3 days 16 hours 25 minutes later every day. Purchase San Francisco bus tickets now.