View Current Travel Advisories

Trailways Bus Tickets
from Big Pine Key, FL to San Diego, CA

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Big Pine Key, FL to San Diego, CA

Buses from Big Pine Key, FL to San Diego, CA travel the 2229mi (3587.22km) journey, taking approximately 3d, 5h, 23m. Usually, there are 6 buses operating per day. While the average ticket price for this journey is around $397.82, you can find the cheapest bus tickets for as low as $385.85.

  • Distance
    2229mi (3587.22km)
  • Average trip duration
  • Average bus ticket price
    $397.82
  • Trips per day
    6
  • Top Carriers
    Greyhound Lines

Bus Station Information for San Diego, CA

San Diego

Bus Station, use arrow keys or tab to explore more about this bus station

San Diego, CA 92110

Bus Station
Address
4005 Taylor Street 
San Diego, CA 92110
Phone Number
(858) 800-8898
More Detailsabout San Diego Bus Station

San Diego (La Jolla - UC San Diego)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Diego, CA 92093

Curbside Stop
Address
UCSD Health La Jolla Station 
San Diego, CA 92093
Phone Number
(858) 800-8898
More Detailsabout San Diego (La Jolla - UC San Diego) Curbside Stop

San Diego (Old Town)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Diego, CA 92110

Curbside Stop
Address
2728 Congress St 
San Diego, CA 92110
Phone Number
(858) 800-8898
More Detailsabout San Diego (Old Town) Curbside Stop

San Diego (SDSU - Hardy Ave)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Diego, CA 92115

Curbside Stop
Address
5716 Hardy Ave 
San Diego, CA 92115
Phone Number
(858) 800-8898
More Detailsabout San Diego (SDSU - Hardy Ave) Curbside Stop

City InformationforBig Pine Key, FL

Take a bus to Big Pine Key, FL, and immerse yourself in the idyllic heart of the Florida Keys. This laid-back town is a slice of paradise where natural beauty and relaxation collide. Known for its stunning landscapes and famous Key deer, the town offers a unique charm that’ll leave you longing for more.

Kick off your adventure with a visit to the National Key Deer Refuge, where you can watch these gentle creatures roam freely. For water enthusiasts, the crystal-clear waters beckon for kayaking or snorkeling trips in the nearby Looe Key Reef. Sun-seekers will love the sandy stretches of Bahia Honda State Park, perfect for unwinding under the swaying palms.

Beyond nature, Big Pine Key serves up a delightful local flair with its quirky shops and eateries. Catch a sunset and maybe even a live music performance at one of the waterfront spots that locals love.

Why wait any longer? Your blissful island escape awaits, so grab your bus tickets to Big Pine Key and let the adventure begin!

City InformationforSan Diego, CA

Pack your flip-flops and hop on a bus to San Diego, CA - where sunny skies and laid-back vibes effortlessly meet. Renowned for its stunning coastline and vibrant culture, San Diego offers budget-friendly adventures and unforgettable experiences. Start your journey in Balboa Park, with its lush gardens and impressive museums, perfect for a leisurely day of exploration.

Beach lovers will find paradise with miles of golden sands at popular spots like Mission Beach or the historic charm of Coronado Beach. Surfing, anyone? Don’t miss a chance to ride the waves at La Jolla Shores. If wildlife is your jam, the San Diego Zoo is world-class and not to be missed.

Dining here is a treat, from casual fish tacos by the shore to rooftop dining with views of that famous sunset. Stroll through the hip neighborhoods of North Park and Gaslamp Quarter for local shops and unique eats. Whatever draws you here, the chill pace of life ensures there's always time for one more adventure. Get started today with a bus to San Diego, CA, and soak in everything this coastal gem offers!

Scenic photo of San Diego, CAScenic photo of San Diego, CAScenic photo of San Diego, CA
Scenic photo of San Diego, CA
Scenic photo of San Diego, CA
Scenic photo of San Diego, CA

Frequently Asked Questions about the Bus Ride

Looking to catch a bus from Big Pine Key to San Diego? Buses depart from Big Pine Key to San Diego 6 times per day. Prices start at $385.85. Comfort, convenience, and affordability. Buy your San Diego bus ticket today.