View Current Travel Advisories
Skip to Main Content
Trailways Home Page

Trailways Bus Tickets
from Portsmouth, NH to San Francisco, CA

Choose one way or round trip:
(*) indicates a required field
Start typing the origin city to open location options, and then use the arrow keys to navigate to the origin city you want, then press enter to select that origin city
Start typing the destination city to open location options, and then use the arrow keys to navigate to the destination city you want, then press enter to select that destination city
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for San Francisco, CA

San Francisco

Bus Station, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94105

Bus Station
Address
425 Mission St. 
San Francisco, CA 94105
Phone Number
(800) 858-8555
More Detailsabout San Francisco Bus Station

San Francisco (5th & Townsend)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94107

Curbside Stop
Address
409 Townsend Street 
San Francisco, CA 94107
Phone Number
(800) 858-8555
More Detailsabout San Francisco (5th & Townsend) Curbside Stop

San Francisco (Fisherman's Wharf)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94109

Curbside Stop
Address
700 Beach Street 
San Francisco, CA 94109
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Fisherman's Wharf) Curbside Stop

San Francisco (Daly City BART)

Curbside Stop, use arrow keys or tab to explore more about this bus station

San Francisco, CA 94014

Curbside Stop
Address
500 John Daly Blvd 
San Francisco, CA 94014
Phone Number
(800) 858-8555
More Detailsabout San Francisco (Daly City BART) Curbside Stop

City InformationforPortsmouth, NH

Looking for a seaside escape with history and charm? Board a bus to Portsmouth, NH, and let this enchanting town surprise you. Known for its colonial-era architecture and vibrant cultural scene, Portsmouth packs a lot into its cozy waterfront setting. Stroll through the narrow streets of the historic district where you'll find beautifully preserved centuries-old homes, unique boutiques, and local cafes with character to spare.

But Portsmouth isn’t just about charming pasts; it’s got a lively present, too. The Prescott Park Arts Festival offers outdoor performances right by the harbor, while theaters in town put on shows that keep the local vibe eclectic and fun. For a deeper dive into maritime history, the USS Albacore Museum will catch any traveler's interest. And when the urge to relax hits, grab a cozy spot at one of the town’s renowned seafood eateries for fresh-off-the-boat fare.

So, why wait? Book your bus to Portsmouth, NH, and experience a destination that makes history incredibly inviting.

City InformationforSan Francisco, CA

When the fog rolls into San Francisco, CA, it's like a cozy invitation to savor a town bursting with iconic charm. Take your next adventure on a bus to San Francisco, and you'll find more delights than just the Golden Gate Bridge. Begin at Fisherman’s Wharf, where street performers add a whimsical touch, and sample world-class seafood. History enthusiasts will love wandering through the haunting walls of Alcatraz Island, while culture vultures can revel in the vast collections within the San Francisco Museum of Modern Art.

For a taste of the local vibe, hop on a cable car and ride through the quirky streets of Haight-Ashbury or explore the vibrant shops and eateries that make Chinatown sing with flavor. Green thumbs (and photographers) shouldn’t miss the Botanical Gardens in Golden Gate Park for a tranquil escape. Whether it’s the distinctive neighborhoods or the panoramic city views from Twin Peaks, every corner of San Francisco is ready to enchant you, especially when you roll into town with the reliable comfort of a Trailways bus.

Scenic photo of San Francisco, CAScenic photo of San Francisco, CAScenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA
Scenic photo of San Francisco, CA

Frequently Asked Questions about the Bus Ride