
Buses from Des Moines, IA to Sioux Falls, SD travel the 332mi (534.30km) journey, taking approximately 10h, 45m. Usually, there are 2 buses operating per day. While the average ticket price for this journey is around $203.53, you can find the cheapest bus tickets for as low as $170.43.
Sioux Falls, SD 57107
All aboard for adventure in Des Moines, IA—a hidden gem in the heart of the Midwest that's sure to surprise and delight. Stepping off your bus to Des Moines, you'll find a town bustling with charm and brimming with activities. Start your exploration at the striking Pappajohn Sculpture Park, where art meets open air. Hungry? The lively East Village offers diverse dining that won't disappoint.
History buffs will enjoy a trip to the State Capitol, a masterpiece of 19th-century architecture with a golden dome that proudly shines over the city. Ready for some fun? Head to Adventureland Park, where thrilling rides await, or unwind in the serene beauty of the Greater Des Moines Botanical Garden.
Des Moines is also famous for its vibrant arts scene, with the Des Moines Art Center leading the charge. And don't forget the Saturday morning Downtown Farmers' Market, splendid any day of the week. Whether it’s art, architecture, or amusement parks, Des Moines serves up a hearty slice of Midwestern hospitality.



Sioux Falls, SD might not be on your radar yet, but once you hop on a bus to Sioux Falls, you'll find a destination with charm to spare. This friendly town is home to stunning natural beauty, buzzing cultural scenes, and enough unique local flavor to keep any traveler entertained. Nature lovers will find themselves drawn to Falls Park, where the picturesque Big Sioux River cascades down glittering tiered rocks, a perfect spot for strolling or snapping a few Instagram-worthy pics. If you're in the mood for art, the SculptureWalk brings Sioux Falls' downtown streets alive with dozens of dynamic sculptures.
What really seals the deal? The city’s bustling downtown offers an array of unique dining experiences and cozy coffee spots where you can unwind like a local. Plus, with street festivals, local music, and that welcoming Midwestern warmth, you're set for a memorable visit. So, when the urge to explore strikes, just grab your bus tickets to Sioux Falls, and let the adventure begin!
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